Protein Expression Market CAGR to be 8.0% by 2035, Due to the Growing Demand For Protein Therapeutics | Roots Analysis

Protein Expression (also referred to as protein production) is a process used to produce large amounts of specific proteins for various therapeutic, research and industrial applications. This process initially involves transcription of DNA to messenger RNA (mRNA). The mRNA is then translated into polypeptide chains, which eventually get folded to form functional proteins.

In the healthcare industry, this process is primarily used for the production of therapeutic biologics and high-value small molecules. In addition, other industries, such as agriculture, cosmetics, food, environmental sciences, biomedical research and enzyme synthesis industry, are also benefiting from the protein expression process. Given the numerous applications of proteins and advancement of several promising protein therapeutics through clinical pipelines, the protein expression is anticipated to become one of the fastest growing markets within the pharmaceutical industry in the coming years.

According to our latest market report the global protein expression market size is projected to reach USD 6.3 billion by 2035 from USD 2.7 billion in 2024, growing at a CAGR of 8.0% in the forecast period 2024-2035.

Market Segments

Based on the type of protein expression system, the market is segmented into algal, cell-free, insect, mammalian, prokaryotic and yeast expression systems.

The mammalian expression system segment led the protein expression market, capturing the largest revenue share of 47% in 2024.

Yeast expression systems segment is anticipated to witness the highest market growth rate of 15.9%, annually during the forecast period.

Based on the protein expression-related offerings, the market is segmented into competent cells, expression vectors, instruments, kits and reagents, and protein expression services.

The kits and reagents segment led the protein expression market, capturing the largest revenue share of 43% in 2024.

In fact, kits and reagents segment is anticipated to witness the highest market growth rate of 8.4%, annually during the forecast period.

Based on the application area, the market is segmented into research and diagnostics, and therapeutics.

The therapeutics segment led the protein expression market, capturing the largest revenue share of close to 65% in 2024.

In fact, therapeutic segment is anticipated to witness the highest market growth rate of 8.6%, annually during the forecast period.

Based on the end-user, the market is segmented into academic and research institutes, CROs and CDMOs, pharmaceutical and biotechnology companies and other end-users.

The pharmaceutical and biotechnology companies led the protein expression market, capturing the largest revenue share of 46% in 2024.

Other end-users segment including hospitals and diagnostic laboratories is anticipated to witness the highest market growth rate of 11.7%, annually during the forecast period.

Based on the type of operation, the market is segmented into in-house and outsourced operations.

The in-house operation segment led the protein expression market, capturing the largest revenue share of 71% in 2024.

In fact, in-house operation segment is anticipated to witness the highest market growth rate of 8.8%, annually during the forecast period.

Based on the Regional Insights, the market is segmented into North America, Europe, and Asia-Pacific, Latin America and, Middle East and North Africa

North America dominated the protein expression market and accounted for the largest revenue share of 50% in 2024.

In Asia-Pacific, the protein expression market is anticipated to demonstrate lucrative growth during the forecast period.

Protein Expression Market Regional Outlook

Based on the key geographical regions, the protein expression market can be segmented into five major regions, including North America, Europe, Asia Pacific, Latin America and Middle East and North Africa. Led by the US, North America is anticipated to capture the majority share of the protein expression market in 2024. The Asia Pacific is accounted to be the fastest-growing segment of the market. The growth of the manufacturing market in this region is primarily driven by technical advancements, rise in skilled population, low labor costs and socio-economic regulatory reforms favoring the growth of the protein expression industry.

Key Report Takeaways

Given the growing pipeline of protein-based therapeutics, complex protein production protocols and high costs associated with protein manufacturing, industry stakeholders rely on novel expression systems with advanced features

The current market landscape is highly fragmented, featuring the presence of both new entrants and established players; of these, more than 45% of expression providers are large and very large players

The players engaged in protein expression domain provide various types of expression systems for various applications including antibody development, vaccine formulation, and structure-based drug design

Considering the wide array of applications of proteins and continuous research efforts of stakeholders in this domain, the adoption of protein expression systems/products is poised to witness a steady growth in the foreseeable future

Mammalian expression systems are anticipated to dominate the overall protein expression market in the coming future, capturing close to 45% share of the overall market, by 2035

Owing to various benefits such as improved efficiency and innovation, in-house operations are expected to capture the largest market share than outsourced operations

Protein Expression Market Key Players

Examples of key companies engaged in protein expression market (which have also been profiled in this market report; the complete list of companies is available in the full report) include Agilent Technologies, Ajinomoto Bio-Pharma Services, Aldevron, Cayman Chemical, Charles River Laboratories, Domainex, Eurofins CALIXAR, GeNext Genomics, GenScript Biotech, Lonza, Merck KGaA, New England BioLabs, ProMab, Promega Corporation, Proteogenix, QIAGEN, Sartorius, Synbio Technologies, Syngene, Takara Bio, Thermo Fisher Scientific and WuXi Biologics.

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